Saturday, May 4, 2013

Toys R Us appeals $20M award in Mass. slide death

This undated family photo provided by Michael Aleo via his attorney shows his Robin Aleo, of Colorado, who died in July 2006 in Andover, Mass., when a pool slide partially collapsed and she slammed her head on the concrete pool deck, causing fatal injuries. Five years later, a jury awarded Aleo?s family more than $20 million, finding the slide sold by Toys R Us did not comply with federal safety standards. Toys R Us will go before the highest court in Massachusetts, on Monday, May 6, 2013, to appeal the ruling. (AP Photo/Aleo Family Photo)

This undated family photo provided by Michael Aleo via his attorney shows his Robin Aleo, of Colorado, who died in July 2006 in Andover, Mass., when a pool slide partially collapsed and she slammed her head on the concrete pool deck, causing fatal injuries. Five years later, a jury awarded Aleo?s family more than $20 million, finding the slide sold by Toys R Us did not comply with federal safety standards. Toys R Us will go before the highest court in Massachusetts, on Monday, May 6, 2013, to appeal the ruling. (AP Photo/Aleo Family Photo)

(AP) ? On a warm summer day in July 2006, Robin Aleo climbed to the top of a 6-foot inflatable pool slide and slid down head first. As she neared the bottom, the slide partially collapsed and Aleo slammed her head on the concrete pool deck, causing fatal injuries.

Five years later, a jury awarded Aleo's family more than $20 million, finding that the slide sold by Toys R Us did not comply with federal safety standards for swimming pool slides.

Toys R Us will go before the highest court in Massachusetts on Monday to ask that the award be overturned.

The national chain argues that the 1976 Consumer Product Safety Commission regulation cited by Aleo's family does not apply to inflatable in-ground pool slides, but only to rigid pool slides. Toys R Us also says the trial judge allowed lawyers for Aleo's family to inflame the jury by accusing Toys R Us of importing an "illegal" product when it had relied on a certification that the slide met all safety regulations.

Aleo, 29, of Louisville, Colo., was visiting relatives in Andover when she went down a "Banzai" pool slide. Her husband, Michael, and 15-month-old daughter were watching as her head hit the pool deck. She suffered a broken neck and died the next day at a Boston hospital.

A jury in Salem Superior Court awarded Aleo's estate $20.6 million in 2011, including $2.5 million in anticipated lost income from Aleo's career in advertising and marketing, $100,000 for pain and suffering before her death and $18 million in punitive damages. Toys R Us argues that the $18 million in punitive damages was "grossly excessive."

Lawyers for Aleo's husband say pool slides have been subject to a federal safety standard since 1976. The standard applies to all pool slides, no matter what they are made of, said Benjamin Zimmermann, a Boston attorney who represents Michael Aleo.

Toys R Us, however, says the standard was only meant to apply to rigid slides, not the flexible, inflatable slides that have become popular in recent years.

"Inflatable slides did not exist (when the regulation was put in place)," Toys R Us lawyers argue in a legal brief filed in its appeal.

The company said the regulation "established performance standards that were designed for rigid slides and that could not be met by an air-filled slide made of fabric like the Inflatable Slide."

But Aleo's family says the regulation applies to all swimming pool slides "regardless of the materials of manufacture or structural characteristics."

The slide had an instruction manual and small warning label near the climbing footholds that said the weight limit was 200 pounds, but the safety standard required that slides should be able to support up to 350 pounds. Aleo weighed 148 pounds, according to testimony at the trial.

A spokeswoman for Toys R Us said the Wayne, N.J.-based company has a policy of not commenting on pending litigation.

In its appeal brief, Toys R Us said the trial judge refused to allow testimony that Aleo had misused the slide and that some witnesses said she had "jumped" or "dived" off the slide head first.

Zimmermann, however, said that witnesses who testified during the trial said Aleo had slid down the slide.

Michael Aleo's aunt and uncle purchased the slide from Toys R Us through Amazon.com. Toys R Us had imported the slides from China, where they were manufactured.

"It was never tested. It carried no required certification that it had been so tested," Zimmermann said.

"Under the federal Consumer Product Safety Commission standards and the Consumer Product Safety Act, products that come into the country without a certification that it's been tested to its applicable standards, the sale of that kind of product is unlawful," he said.

The commission announced in May 2012 that Toys R Us and Wal-Mart stores were recalling the slides, citing Aleo's death and injuries suffered by two other people, including a 24-year-old man from Springfield, Mo., who became a quadriplegic and a woman from Allentown, Pa., who fractured her neck.

The Aleo case has drawn the attention of the Toy Industry Association Inc., a trade group whose nearly 600 members account for about 85 percent of the annual U.S. domestic toy market. The group filed a friend-of-the-court brief supporting Toys R Us in its position that the consumer safety regulation does not apply to inflatable pool slides.

The group says the safety commission never considered applying the rule to "constant air inflatable" slides because they didn't exist when the rule was written in the 1970s.

"In any event, the safety hazard that plaintiff alleged ? injury due to the loss of air pressure ? was not among the risks that the Commission considered," the group argues in its brief.

The group says applying the regulation to inflatable slides "goes beyond Congress's authorization for consumer product safety rules."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-05-04-Pool%20Slide%20Death/id-0cec902de8024265b84623e0e1b02547

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Friday, May 3, 2013

Moon: Tebow can't cut it in CFL

TebowAP

The only noise on the Tim Tebow front seems to be from those shouting him down.

But it sounds like the former Jets backup is growing realistic about his plight, while looking for a specific set of conditions to help fix it.

According to Jason Cole of Yahoo! Sports, Tebow would ?like to go where he can sit, learn behind great quarterback and coach. New Orleans would be perfect, for example.?

Well, yeah.

While that doesn?t take into account whether the Saints (or anyone) has any interest in him, it does point to one important fact, perhaps the most important.

Tebow may realize he?s broken.

A week with Vinny Testaverde might have helped, but if he?s ever going to be more than just a ?leader,? and perhaps some day a ?passer,? he?s going to need full-time tutoring. Specifically, someone to teach him how to play the game correctly, and someone who can tap into the talents he does have, while polishing the ones he doesn?t.

He picked the Jets over the Jaguars a year ago for reasons that didn?t seem entirely motivated by football. But if he?s willing to ratchet back his expectations off the field, and concentrate on getting better on the field, there still may be a chance to salvage something.

Whether anyone?s willing to help him toward that goal remains to be seen. The conditions it sounds like he?s seeking don?t exist many places, if we?re being honest. New Orleans, New England for sure, maybe Green Bay and a few others.

But if Tebow realizes he needs to be more concerned about the journey toward becoming a player than the destination, he might he halfway there.

Source: http://profootballtalk.nbcsports.com/2013/05/02/warren-moon-says-the-cfl-is-no-place-for-tebow/related/

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Winds ease but Calif. wildfire threat remains

CAMARILLO, Calif. (AP) ? A huge Southern California wildfire carved a path to the sea and burned on the beach Friday, but firefighters got a break as gusty Santa Ana winds turned into breezes.

Temperatures remained high, but humidity levels were expected to soar as cool air moved in from the ocean and the Santa Anas retreated.

At the same time, the reversal of wind direction carried the risk of sending flames in new, dangerous directions.

"It could move just as quickly coming the other way," said Bill Nash, a Ventura County fire spokesman.

The wind-whipped fire erupted Thursday in the Camarillo area, threatening as many as 4,000 homes but only damaging 15, Nash said.

The 15 1/2-square-mile blaze was only 10 percent contained on Friday, and the work of more than 900 firefighters, aided by air tankers, was just beginning.

Evacuations were lifted overnight for neighborhoods as the fire moved toward the coast. California State University, Channel Islands remained closed, and new evacuations were called for coastal canyons, Nash said.

He did not know how many homes were immediately threatened but said the area mainly included ranches, orchards, camps and vacation homes rather than dense neighborhoods. Some expensive ridge-top and canyon homes also were in the path of the flames. Fire engine crews took up positions to defend the dwellings as helicopters made water drops.

The fire was 20 miles from Malibu, burning mostly in rugged mountains. It jumped the Pacific Coast Highway at Point Mugu and burned on a beach shooting range of Naval Base Ventura County.

The base ordered an evacuation of a nearby housing area as a precautionary measure and urged personnel in other Point Mugu housing to voluntarily leave.

The fire reinforced predictions that California is in for a bad summer fire season because dry winter and spring weather has left brush tinder-dry.

In addition, the California Department of Water Resources found the water content in the snowpack was just 17 percent of normal. The snowmelt is a vital water source for the state.

More than 3,000 firefighters were battling six major wildfires on Friday in California, the state fire agency said.

Fire crews have responded to more than 680 wildfires since the beginning of the year ? some 200 more than average for the period.

Hot, dry Santa Ana winds gusting to 50 mph or more swept flames from the Camarillo-area fire toward the coast on Thursday.

Cooler, calmer ocean air was beginning to move ashore on Friday and could send the humidity soaring ? the beginning of change that could even bring a chance of rain in the fire area by Sunday night or Monday morning.

The change pushed relative humidity at Camarillo from just 3 percent to 19 percent in an hour. The temperature hit 96 then fell into the low 80s. Smoke that had been streaming offshore began stagnating over the fire.

The National Weather Service canceled mountain wind advisories and predicted onshore winds of only 10 mph to 15 mph, with some 20 mph gusts.

The change had been expected to begin later in the afternoon but its early arrival was a potential mixed blessing for fire crews.

"They'll have to be on their toes as far as a wind shift. Now the fire will have to move the other direction," said Eric Boldt, warning coordination meteorologist with the National Weather Service in Oxnard.

That raised concerns of flare-ups along the path of the fire.

"The fire can jump up at any time and any place," Tom Kruschke, a Ventura County fire spokesman, said earlier. "There's that hot bed of coals out there covering thousands of acres."

Overnight, the fire roared down a canyon in Point Mugu State Park and through an evacuated campground, but firefighters managed to protect a nature center and other buildings.

"We had 20-, 25-foot flames. They were having a devil of a time making a stand," said Craig Sap, a state parks supervisor for the district.

"We had a moment of calmness, maybe a wind shift, and they were able to get a line around it," he said. "I don't think a single picnic bench burned."

Elsewhere in Ventura County, a 4 1/2-square-mile blaze that destroyed a home burned for a third day in mountains north of Banning. It was 65 percent contained.

In Tehama County in Northern California, the size of a wildfire north of Butte Meadows was revised down from more than 15 square miles to 10 square miles, state fire spokesman Daniel Berlant said.

The fire, which was 10 percent contained, was burning in a remote area and wasn't posing an imminent threat to any structures.

Elsewhere, crews expected to fully contain a 125-acre blaze in Sonoma County and a 200-acre fire in Glenn County on Friday.

Containment of a 55-acre Butte County fire was expected this weekend.

Source: http://news.yahoo.com/winds-ease-calif-wildfire-threat-remains-173604959.html

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Hearing the Russian meteor, in America

May 3, 2013 ? How powerful was February's meteor that crashed into Russia? Strong enough that its explosive entry into our atmosphere was detected almost 6,000 miles away in Lilburn, Ga., by infrasound sensors -- a full 10 hours after the meteor's explosion. A Georgia Tech researcher has modified the signals and made them audible, allowing audiences to "hear" what the meteor's waves sounded like as they moved around the globe on February 15.

Lilburn is home to one of nearly 400 USArray seismic/infrasound stations in use in the eastern United States. They are part of a large-scale project named "Earthscope," an initiative funded by the National Science Foundation that studies Earth's interior beneath North America. The stations are mainly deployed to record seismic waves generated from earthquakes, but their sound sensors can record ultra long-period sound waves, also known as infrasound waves.

The human ear cannot hear these infrasound signals. However, by playing the data faster than true speed, Georgia Tech faculty member Zhigang Peng increased the sound waves' frequency to audible levels. The Incorporated Research Institutions for Seismology's Data Managment Center provided the data.

"The sound started at about 10 hours after the explosion and lasted for another 10 hours in Georgia," said Peng, an associate professor in the School of Earth and Atmospheric Sciences. He's confident that the sound is associated with the meteor impact because a slow propagation of the sound waves can be seen across the entire collection of USArray stations, as well as other stations in Alaska and polar regions.

"They are like tsunami waves induced by large earthquakes," Peng added. "Their traveling speeds are similar, but the infrasound propagates in the atmosphere rather than in deep oceans."

Scientists believe the meteor was about 55 feet in diameter, weighed more than 7,000 tons and raced through the sky at 40,000 miles an hour. Its energy was estimated at 30 nuclear bombs. More than 1,500 people were hurt.

Using the same sonification process, Peng also converted seismic waves from North Korea's nuclear test on February 12 and an earthquake in Nevada the next day. Each registered as a 5.1 magnitude event but created different sounds. The measurements were collected by seismic instruments located about 100 to 200 miles from each event. For further comparison, Peng has also created a seismic recording of the meteor impact at a similar distance.

"The initial sound of the nuclear explosion is much stronger, likely due to the efficient generation of compressional wave (P wave) for an explosive source," said Peng. "In comparison, the earthquake generated stronger shear waves that arrived later than its P wave."

Peng says the seismic signal from the meteor is relatively small, even after being amplified by 10 times. According to Peng, this is mainly because most of the energy from the meteor explosion propagated as the infrasound displayed in the initial sound clip. Only a very small portion was turned into seimsic waves propagating inside Earth.

This isn't the first time Peng has converted seismic data into audible files. He also sonified 2011's historic Tohoku-Oki, Japan, earthquake as it moved through Earth and around the globe.

The seismic and sound data generated by the meteor impact and other sources can be used to demonstrate their global impact. Scientists are also using them to better understand their source characterizations and how they propagate above and inside Earth.

Video: https://www.youtube.com/watch?v=i1ey5zc6TOo

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/7mm1Fm5d-a8/130503105033.htm

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Giant rubber duck sails into Hong Kong harbor

The 54-foot-tall rubber duck makes its way into Hong Kong's Victoria Harbour (Bobby Yip/Reuters)

It was like something out of a Ducks Unlimited member?s dreams: A 54-foot-tall rubber duck sailed into a Hong Kong harbor on Thursday.

Hundreds gathered at Victoria Harbour to cheer the arrival of the duck, which was designed by Dutch artist Flortentijn Hofman. The enormous duckling was built in 2007 and has since traveled to 13 cities and nine countries.

"My sculptures cause an uproar, astonishment and put a smile on your face," Hoffman told the Daily Mail. "They give people a break from their daily routines. Passers-by stop in front of them and enter into conversation with other spectators. People are making contact with each other again."

You can watch a slideshow of the Rubber Duck's arrival below:

So does the duck have a specific message for the people of the world?

Well, sort of. On Hofman?s website, he offers the following explanation for the history of his creation: ?The Rubber Duck knows no frontiers, it doesn't discriminate people and doesn't have a political connotation. The friendly, floating Rubber Duck has healing properties: it can relieve mondial tensions as well as define them. The rubber duck is soft, friendly and suitable for all ages!?

Source: http://news.yahoo.com/blogs/sideshow/50-foot-rubber-duck-sails-hong-kong-harbor-190949396.html

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Keeping Up With the Kardashians Promo: The Most Unexpected Season Ever!

Source: http://www.thehollywoodgossip.com/2013/05/keeping-up-with-the-kardashians-promo-the-most-unexpected-season/

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It slices, it dices, it silences: ADAR1 as gene-silencing modular RNA multitool

Thursday, May 2, 2013

RNA, once considered a bit player in the grand scheme by which genes encode protein, is increasingly seen to have a major role in human genetics. In a study presented in the April 25 issue of the journal Cell, researchers from The Wistar Institute discovered how the RNA-editing protein, ADAR1, also combines with the protein called Dicer to create microRNA (miRNA) and small interfering (siRNA). These varieties of RNA, in turn, play a crucial role in gene regulation--silencing or "switching off" the production of specific proteins.

Upward of 60 percent of mammalian genes are thought to be targeted and regulated by non-coding RNA molecules, researchers say. This aspect of RNA biology is so critical to life, in fact, that the Nishikura laboratory demonstrated how a lack of ADAR1 was lethal in embryonic mice.

"Our evidence suggests that regulation of the microRNA synthesis is critical for life, and we have determined that the regulation is orchestrated by the RNA editing protein ADAR1," said Kazuko Nishikura, Ph.D., a professor in Wistar's Gene Expression and Regulation program and senior author of the study. "We see here this remarkable evolutionary ingenuity, where ADAR1 can combine with other enzymes to serve different roles in RNA functions, like a molecular Swiss army knife."

The genome, in the form of DNA, contains the instructions for both new proteins and the RNA that helps regulate how protein production is controlled. No longer just seen in the form messenger RNA (mRNA)--delivering transcribed genetic blueprints from DNA to the cellular factories that build proteins. Numerous varieties of RNA, such as non-coding RNA, have been described that hold important roles in many facets of our cellular biology. "Non-coding RNA that do not code for proteins seem to have an overt and pervasive role in overseeing our genome," Nishikura said.

For more than 20 years following the discovery and definition of the ADAR family of proteins, Nishikura's laboratory has been a leader in the study of RNA biology. The ADAR proteins (the acronym stands for "Adenosine deaminases acting on RNA") literally edit RNA molecules, changing the "letters" of RNA from A to I (turning the adenosine subunit of RNA into the inosine subunit). A to I alteration can significantly affect biological function, such as altering brain chemistry, for example, by influencing the production of neurotransmitters.

In response to recent reports that ADAR1 was antagonistic to the chemical pathways that determine how RNA silences genes, Nishikura found, to the contrary, that the protein was a critical part of the process. The ADAR1 molecule operates as a "dimer," where two copies of ADAR1 bind together to form the complete protein. As Nishikura determined, a single copy of ADAR1 binds to the Dicer protein, a protein known to literally chop RNA molecules into miRNA.

This ADAR1-Dicer arrangement has the effect of helping to feed RNA to the enzyme. Additionally, ADAR1 helps load these newly-born miRNAs into RNA-induced silencing complexes (RISCs), large arrangements of multiple proteins that incorporate miRNA or siRNA, in order to target and neutralize specific messenger RNA molecules, thereby preventing a specific gene from producing a protein.

"The RNA regulation of our genome is still a field in its infancy," Nishikura explained. "The ability to regulate genetics in this way is amazingly versatile and powerful. It is also a field that has many potential lessons?or direct applications?for human medicine."

###

The Wistar Institute: http://www.wistar.org

Thanks to The Wistar Institute for this article.

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Source: http://www.labspaces.net/128096/It_slices__it_dices__it_silences__ADAR__as_gene_silencing_modular_RNA_multitool

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